Mapping land use/land cover (LULC) changes at regional scales is essential for a wide range of applications, including landslide, erosion, land planning, global warming etc. LULC alterations (based especially on human activities), negatively effect the patterns of climate, the patterns of natural hazard and socio-economic dynamics in global and local scale. In this study, LULC changes are investigated by using of Remote Sensing and Geographic Information Systems (GIS) in Rize, North-East Turkey. For this purpose, firstly supervised classification technique is applied to Landsat images acquired in 1976 and 2000. Image Classification of six reflective bands of two Landsat images is carried out by using maximum likelihood method with the aid of ground truth data obtained from aerial images dated 1973 and 2002. The second part focused on land use land cover changes by using change detection comparison (pixel by pixel). In third part of the study, the land cover changes are analyzed according to the topographic structure (slope and altitude) by using GIS functions. The results indicate that severe land cover changes have occurred in agricultural (36.2%) (especially in tea gardens), urban (117%), pasture (-72.8%) and forestry (-12.8%) areas has been experienced in the region between 1976 and 2000. It was seen that the LULC changes were mostly occurred in coastal areas and in areas having low slope values.